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ENZYME entry: EC 1.13.12.7

Accepted Name
Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing).
Alternative Name(s)
Firefly luciferase.
Luciferase.
Photinus pyralis luciferase.
Reaction catalysed
Photinus luciferin + O(2) + ATP <=> oxidized Photinus luciferin + CO(2) + AMP + diphosphate + light
Comment(s)
  • Photinus (firefly) is a bioluminescent insect.
  • The first step in the reaction is the formation of an acid anhydride between the carboxylic group and AMP, with the release of diphosphate.
  • The enzyme may be assayed by measurement of light emission.
Cross-references
PROSITEPDOC00427
BRENDA1.13.12.7
EC2PDB1.13.12.7
ExplorEnz1.13.12.7
PRIAM enzyme-specific profiles1.13.12.7
KEGG Ligand Database for Enzyme Nomenclature1.13.12.7
IUBMB Enzyme Nomenclature1.13.12.7
IntEnz1.13.12.7
MEDLINEFind literature relating to 1.13.12.7
MetaCyc1.13.12.7
UniProtKB/Swiss-Prot
P13129, LUCI_LUCCR;  Q01158, LUCI_LUCLA;  Q26304, LUCI_LUCMI;  
Q27757, LUCI_PHOPE;  P08659, LUCI_PHOPY;  

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