ENZYME entry: EC 1.14.11.19

Accepted Name
Leucocyanidin oxygenase.
Alternative Name(s)
Anthocyanidin synthase.
Leucoanthocyanidin dioxygenase.
Reaction catalysed
Leucocyanidin + 2-oxoglutarate + O(2) <=> cis- and trans-dihydroquercetins + succinate + CO(2) + H(2)O
Cofactor(s)
Fe(2+); L-ascorbate.
Comment(s)
  • Involved in the pathway by which many flowering plants make anthocyanin (glycosylated anthocyandin) flower pigments.
  • The intermediates are transformed into cis- and trans- dihydroquercetin, which the enzyme can also oxidize to quercetin.
  • Acidification of the products gives anthocyanidin, which, however, may not be a natural precursor of the anthocyanins.
Cross-references
PROSITEPDOC51471
BRENDA1.14.11.19
EC2PDB1.14.11.19
ExplorEnz1.14.11.19
PRIAM enzyme-specific profiles1.14.11.19
KEGG Ligand Database for Enzyme Nomenclature1.14.11.19
IUBMB Enzyme Nomenclature1.14.11.19
IntEnz1.14.11.19
MEDLINEFind literature relating to 1.14.11.19
MetaCyc1.14.11.19
UniProtKB/Swiss-Prot
Q96323, LDOX_ARATH;  P41213, LDOX_MAIZE;  P51091, LDOX_MALDO;  
O04274, LDOX_PERFR;  P51092, LDOX_PETHY;  P51093, LDOX_VITVI;  

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