ENZYME entry: EC 1.14.11.2

Accepted Name
Procollagen-proline dioxygenase.
Alternative Name(s)
Procollagen-proline 4-dioxygenase.
Procollagen-proline,2-oxoglutarate-4-dioxygenase.
Proline hydroxylase.
Proline,2-oxoglutarate 4-dioxygenase.
Prolyl 4-hydroxylase.
Prolyl hydroxylase.
Protocollagen hydroxylase.
Reaction catalysed
L-proline-[procollagen] + 2-oxoglutarate + O(2) <=> trans-4-hydroxy-L-proline-[procollagen] + succinate + CO(2)
Cofactor(s)
Iron; L-ascorbate.
Cross-references
PROSITEPDOC00172 ; PDOC51471
BRENDA1.14.11.2
EC2PDB1.14.11.2
ExplorEnz1.14.11.2
PRIAM enzyme-specific profiles1.14.11.2
KEGG Ligand Database for Enzyme Nomenclature1.14.11.2
IUBMB Enzyme Nomenclature1.14.11.2
IntEnz1.14.11.2
MEDLINEFind literature relating to 1.14.11.2
MetaCyc1.14.11.2
UniProtKB/Swiss-Prot
F4JZ24, P4H10_ARATH;  Q9SZT0, P4H11_ARATH;  Q8GXT7, P4H12_ARATH;  
F4ILF8, P4H13_ARATH;  Q9ZW86, P4H1_ARATH;  F4JAU3, P4H2_ARATH;  
Q9LN20, P4H3_ARATH;  Q8LAN3, P4H4_ARATH;  Q24JN5, P4H5_ARATH;  
F4J0A8, P4H6_ARATH;  Q8L970, P4H7_ARATH;  Q8VZJ7, P4H9_ARATH;  
Q1RMU3, P4HA1_BOVIN;  Q10576, P4HA1_CAEEL;  P16924, P4HA1_CHICK;  
P13674, P4HA1_HUMAN;  Q60715, P4HA1_MOUSE;  Q5RAG8, P4HA1_PONAB;  
P54001, P4HA1_RAT;  Q20065, P4HA2_CAEEL;  Q5ZLK5, P4HA2_CHICK;  
O15460, P4HA2_HUMAN;  Q60716, P4HA2_MOUSE;  Q75UG4, P4HA3_BOVIN;  
Q7Z4N8, P4HA3_HUMAN;  Q6W3F0, P4HA3_MOUSE;  Q6W3E9, P4HA3_RAT;  
Q5UP57, P4H_MIMIV;  

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