ENZYME entry: EC 1.14.11.21
| Accepted Name |
|---|
| Clavaminate synthase.
|
| Alternative Name(s) |
|---|
| Clavaminic acid synthase. |
| Reaction catalysed |
|---|
- Deoxyamidinoproclavaminate + 2-oxoglutarate + O(2) <=> amidinoproclavaminate + succinate + CO(2)
- Proclavaminate + 2-oxoglutarate + O(2) <=> dihydroclavaminate + succinate + CO(2) + H(2)O
- Dihydroclavaminate + 2-oxoglutarate + O(2) <=> clavaminate + succinate + CO(2) + H(2)O
|
| Cofactor(s) |
|---|
| Iron.
|
| Comment(s) |
|---|
- Catalyzes three separate oxidative reactions in the pathway for the
biosythesis of the beta-lactamase inhibitor clavulanate in
Streptomyces clavuligerus.
- The first step (hydroxylation) is separated from the latter two
(oxidative cyclization and desaturation) by the action of
EC 3.5.3.22.
- The three reactions are all catalyzed at the same nonheme iron site.
|
| Cross-references |
|---|
| BRENDA | 1.14.11.21 |
| EC2PDB | 1.14.11.21 |
| ExplorEnz | 1.14.11.21 |
| PRIAM enzyme-specific profiles | 1.14.11.21 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.21 |
| IUBMB Enzyme Nomenclature | 1.14.11.21 |
| IntEnz | 1.14.11.21 |
| MEDLINE | Find literature relating to 1.14.11.21 |
| MetaCyc | 1.14.11.21 |
| UniProtKB/Swiss-Prot |
|
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