ENZYME entry: EC 1.14.11.23

Accepted Name
Flavonol synthase.
Alternative Name(s)
Flavonoid 2-oxoglutarate-dependent dioxygenase.
FLS.
Reaction catalysed
A dihydroflavonol + 2-oxoglutarate + O(2) <=> a flavonol + succinate + CO(2) + H(2)O
Cofactor(s)
Fe(2+).
Comment(s)
In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from the satsuma Citrus unshiu also has a non- specific activity that trans-hydroxylates the flavanones (2S)- naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively.
Cross-references
PROSITEPDOC51471
BRENDA1.14.11.23
EC2PDB1.14.11.23
ExplorEnz1.14.11.23
PRIAM enzyme-specific profiles1.14.11.23
KEGG Ligand Database for Enzyme Nomenclature1.14.11.23
IUBMB Enzyme Nomenclature1.14.11.23
IntEnz1.14.11.23
MEDLINEFind literature relating to 1.14.11.23
MetaCyc1.14.11.23
UniProtKB/Swiss-Prot
Q96330, FLS1_ARATH;  Q9FFQ5, FLS3_ARATH;  F4KAS1, FLS4_ARATH;  
Q9FFQ4, FLS5_ARATH;  F4K7D5, FLS6_ARATH;  Q9ZWQ9, FLS_CITUN;  
Q9M547, FLS_EUSER;  Q9XHG2, FLS_MALDO;  O04395, FLS_MATIN;  
Q7XZQ6, FLS_PETCR;  Q07512, FLS_PETHY;  Q41452, FLS_SOLTU;  

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