ENZYME entry: EC 1.14.11.26

Accepted Name
Deacetoxycephalosporin-C hydroxylase.
Alternative Name(s)
3'-methylcephem hydroxylase.
DACS.
DAOC hydroxylase.
Deacetoxycephalosporin C hydroxylase.
Deacetylcephalosporin C synthase.
Reaction catalysed
Deacetoxycephalosporin C + 2-oxoglutarate + O(2) <=> deacetylcephalosporin C + succinate + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
  • The enzyme can also use 3-exomethylenecephalosporin C as a substrate to form deacetoxycephalosporin C, although more slowly.
  • In Acremonium chrysogenum, the enzyme forms part of a bifunctional protein along with EC 1.14.20.1.
  • It is a separate enzyme in Streptomyces clavuligerus.
Cross-references
PROSITEPDOC00165 ; PDOC51471
BRENDA1.14.11.26
EC2PDB1.14.11.26
ExplorEnz1.14.11.26
PRIAM enzyme-specific profiles1.14.11.26
KEGG Ligand Database for Enzyme Nomenclature1.14.11.26
IUBMB Enzyme Nomenclature1.14.11.26
IntEnz1.14.11.26
MEDLINEFind literature relating to 1.14.11.26
MetaCyc1.14.11.26
UniProtKB/Swiss-Prot
P42219, CEFF_AMYLA;  P42220, CEFF_STRCL;  P11935, EXPA_ACRCH;  

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