ID   1.14.11.27
DE   [histone H3]-dimethyl-L-lysine(36) demethylase.
AN   [histone-H3]-lysine-36 demethylase.
AN   H3-K36-specific demethylase.
AN   histone demethylase.
AN   histone-lysine (H3-K36) demethylase.
AN   JHDM1A.
AN   JmjC domain-containing histone demethylase 1A.
CA   2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 =
CA   2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate.
CC   -!- Requires iron(II).
CC   -!- Of the seven potential methylation sites in histones H3 (K4, K9, K27,
CC       K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific
CC       for Lys(36).
CC   -!- Lysine residues exist in three methylation states (mono-, di- and
CC       trimethylated).
CC   -!- The enzyme preferentially demethylates the dimethyl form of Lys(36)
CC       (K36me2), which is its natural substrate, to form the monomethylated
CC       and unmethylated forms of Lys(36).
CC   -!- It can also demethylate monomethylated (but not the trimethylated)
CC       Lys(36), cf. EC 1.14.11.69.
DR   Q4WHB7, JHD1_ASPFU ;  Q60V67, JHD1_CAEBR ;  Q95Q98, JHD1_CAEEL ;
DR   Q5A847, JHD1_CANAL ;  Q6FPL6, JHD1_CANGA ;  P0CO41, JHD1_CRYNB ;
DR   P0CO40, JHD1_CRYNJ ;  Q6BXJ4, JHD1_DEBHA ;  Q9VHH9, JHD1_DROME ;
DR   Q5AW75, JHD1_EMENI ;  Q75AL5, JHD1_EREGS ;  Q6CIC9, JHD1_KLULA ;
DR   O94603, JHD1_SCHPO ;  Q4P5U1, JHD1_USTMA ;  Q6C423, JHD1_YARLI ;
DR   P40034, JHD1_YEAST ;  Q8RWR1, JMJ30_ARATH;  Q9Y2K7, KDM2A_HUMAN;
DR   P59997, KDM2A_MOUSE;  Q5U263, KDM2A_XENTR;  Q8NHM5, KDM2B_HUMAN;
DR   Q6P1G2, KDM2B_MOUSE;  Q640I9, KDM2B_XENLA;  A8E534, KDM8_DANRE ;
DR   B5XF11, KDM8_SALSA ;  B2GUS6, KDM8_XENTR ;  Q16W06, NO66_AEDAE ;
DR   C3XRY1, NO66_BRAFL ;  A8QFQ3, NO66_BRUMA ;  A8XEA2, NO66_CAEBR ;
DR   O01658, NO66_CAEEL ;  B0WMG3, NO66_CULQU ;  Q54K96, NO66_DICDI ;
DR   B3MSI4, NO66_DROAN ;  B3NU20, NO66_DROER ;  B4JMQ2, NO66_DROGR ;
DR   Q7K4H4, NO66_DROME ;  B4L6Q5, NO66_DROMO ;  B4GUZ2, NO66_DROPE ;
DR   B5DUH6, NO66_DROPS ;  B4I100, NO66_DROSE ;  B4R4H1, NO66_DROSI ;
DR   B4M7P8, NO66_DROVI ;  B4NP88, NO66_DROWI ;  B4Q068, NO66_DROYA ;
DR   P0CH95, PHF8_DANRE ;  Q9UPP1, PHF8_HUMAN ;  Q80TJ7, PHF8_MOUSE ;
DR   A5PK74, RIOX1_BOVIN;  Q5ZMM1, RIOX1_CHICK;  A3KP59, RIOX1_DANRE;
DR   Q9H6W3, RIOX1_HUMAN;  Q9JJF3, RIOX1_MOUSE;  D3ZU57, RIOX1_RAT  ;
//