ID   1.14.11.29
DE   hypoxia-inducible factor-proline dioxygenase.
AN   HIF hydroxylase.
CA   2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 =
CA   CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor
CA   alpha subunit].
CC   -!- Contains iron, and requires ascorbate.
CC   -!- Specifically hydroxylates a proline residue in HIF-alpha, the alpha
CC       subunit of the transcriptional regulator HIF (hypoxia-inducible
CC       factor), which targets HIF for proteasomal destruction.
CC   -!- The requirement of oxygen for the hydroxylation reaction enables
CC       animals to respond to hypoxia.
DR   G5EBV0, EGL9_CAEEL ;  Q9GZT9, EGLN1_HUMAN;  Q91YE3, EGLN1_MOUSE;
DR   P59722, EGLN1_RAT  ;  Q96KS0, EGLN2_HUMAN;  Q91YE2, EGLN2_MOUSE;
DR   Q6AYU4, EGLN2_RAT  ;  Q9H6Z9, EGLN3_HUMAN;  Q91UZ4, EGLN3_MOUSE;
DR   Q62630, EGLN3_RAT  ;  Q9NXG6, P4HTM_HUMAN;  Q8BG58, P4HTM_MOUSE;
//