ENZYME entry: EC 1.14.11.30

Accepted Name
Hypoxia-inducible factor-asparagine dioxygenase.
Alternative Name(s)
HIF hydroxylase.
Reaction catalysed
Hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O(2) <=> hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO(2)
Cofactor(s)
Fe(2+); L-ascorbate.
Comment(s)
  • Contains iron, and requires ascorbate.
  • Catalyzes hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300.
  • The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
Cross-references
BRENDA1.14.11.30
EC2PDB1.14.11.30
ExplorEnz1.14.11.30
PRIAM enzyme-specific profiles1.14.11.30
KEGG Ligand Database for Enzyme Nomenclature1.14.11.30
IUBMB Enzyme Nomenclature1.14.11.30
IntEnz1.14.11.30
MEDLINEFind literature relating to 1.14.11.30
MetaCyc1.14.11.30
UniProtKB/Swiss-Prot
P59723, HIF1N_DANRE;  Q9NWT6, HIF1N_HUMAN;  Q8BLR9, HIF1N_MOUSE;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-