ENZYME entry: EC 1.14.11.30
| Accepted Name |
|---|
| Hypoxia-inducible factor-asparagine dioxygenase.
|
| Alternative Name(s) |
|---|
| HIF hydroxylase. |
| Reaction catalysed |
|---|
| Hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O(2) <=> hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO(2) |
| Cofactor(s) |
|---|
| Iron; L-ascorbate.
|
| Comment(s) |
|---|
- Contains iron, and requires ascorbate.
- Catalyzes hydroxylation of an asparagine in the C-terminal
transcriptional activation domain of HIF-alpha, the alpha subunit of
the transcriptional regulator HIF (hypoxia-inducible factor), which
reduces its interaction with the transcriptional coactivator protein
p300.
- The requirement of oxygen for the hydroxylation reaction enables
animals to respond to hypoxia.
|
| Cross-references |
|---|
| BRENDA | 1.14.11.30 |
| EC2PDB | 1.14.11.30 |
| ExplorEnz | 1.14.11.30 |
| PRIAM enzyme-specific profiles | 1.14.11.30 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.30 |
| IUBMB Enzyme Nomenclature | 1.14.11.30 |
| IntEnz | 1.14.11.30 |
| MEDLINE | Find literature relating to 1.14.11.30 |
| MetaCyc | 1.14.11.30 |
| UniProtKB/Swiss-Prot |
|
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