ID 1.14.11.32 DE codeine 3-O-demethylase. AN codeine O-demethylase. CA codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + CA CO2. CC -!- Requires Fe(2+). CC -!- Catalyzes a step in morphine biosynthesis. CC -!- The enzyme also catalyzes the 3-O-demethylation of thebaine to CC oripavine, with lower efficiency. DR D4N502, DIOX3_PAPSO; //