ENZYME entry: EC 1.14.11.33

Accepted Name
DNA oxidative demethylase.
Alternative Name(s)
Alkylated DNA repair protein.
Reaction catalysed
DNA-base-CH(3) + 2-oxoglutarate + O(2) <=> DNA-base + formaldehyde + succinate + CO(2)
Cofactor(s)
Fe cation.
Comment(s)
  • Activity is slightly stimulated by ascorbate.
  • Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine.
  • It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
Cross-references
BRENDA1.14.11.33
EC2PDB1.14.11.33
ExplorEnz1.14.11.33
PRIAM enzyme-specific profiles1.14.11.33
KEGG Ligand Database for Enzyme Nomenclature1.14.11.33
IUBMB Enzyme Nomenclature1.14.11.33
IntEnz1.14.11.33
MEDLINEFind literature relating to 1.14.11.33
MetaCyc1.14.11.33
UniProtKB/Swiss-Prot
Q13686, ALKB1_HUMAN;  P0CB42, ALKB1_MOUSE;  Q9SIE0, ALKB2_ARATH;  
Q58DM4, ALKB2_BOVIN;  Q6NS38, ALKB2_HUMAN;  Q6P6J4, ALKB2_MOUSE;  
B8GWW6, ALKB_CAUCN;  P0CAT7, ALKB_CAUCR;  P05050, ALKB_ECOLI;  
P37462, ALKB_SALTY;  

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