ENZYME entry: EC 1.14.11.39

Accepted Name
L-asparagine oxygenase.
Alternative Name(s)
L-asparagine 3-hydroxylase.
Reaction catalysed
L-asparagine + 2-oxoglutarate + O(2) <=> (2S,3S)-3-hydroxyasparagine + succinate + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
  • The enzyme is only able to hydroxylate free L-asparagine.
  • It is not active toward D-asparagine.
  • The beta-hydroxylated asparagine produced is incorporated at position 9 of the calcium-dependent antibiotic (CDA), an 11-residue non- ribosomally synthesized acidic lipopeptide lactone.
  • Formerly EC 1.14.11.n1.
Cross-references
BRENDA1.14.11.39
EC2PDB1.14.11.39
ExplorEnz1.14.11.39
PRIAM enzyme-specific profiles1.14.11.39
KEGG Ligand Database for Enzyme Nomenclature1.14.11.39
IUBMB Enzyme Nomenclature1.14.11.39
IntEnz1.14.11.39
MEDLINEFind literature relating to 1.14.11.39
MetaCyc1.14.11.39
UniProtKB/Swiss-Prot
Q9Z4Z5, ASNO_STRCO

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