ENZYME entry: EC 1.14.11.4

Accepted Name
Procollagen-lysine 5-dioxygenase.
Alternative Name(s)
Lysine hydroxylase.
Lysine,2-oxoglutarate 5-dioxygenase.
Lysyl hydroxylase.
Procollagen-lysine,2-oxoglutarate 5-dioxygenase.
Reaction catalysed
L-lysine-[procollagen] + 2-oxoglutarate + O(2) <=> (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO(2)
Cofactor(s)
Iron; L-ascorbate.
Cross-references
PROSITEPDOC01028 ; PDOC51471
BRENDA1.14.11.4
EC2PDB1.14.11.4
ExplorEnz1.14.11.4
PRIAM enzyme-specific profiles1.14.11.4
KEGG Ligand Database for Enzyme Nomenclature1.14.11.4
IUBMB Enzyme Nomenclature1.14.11.4
IntEnz1.14.11.4
MEDLINEFind literature relating to 1.14.11.4
MetaCyc1.14.11.4
UniProtKB/Swiss-Prot
O77588, PLOD1_BOVIN;  P24802, PLOD1_CHICK;  Q02809, PLOD1_HUMAN;  
Q9R0E2, PLOD1_MOUSE;  Q5R9N3, PLOD1_PONAB;  Q63321, PLOD1_RAT;  
O00469, PLOD2_HUMAN;  Q9R0B9, PLOD2_MOUSE;  Q811A3, PLOD2_RAT;  
O60568, PLOD3_HUMAN;  Q9R0E1, PLOD3_MOUSE;  Q5R6K5, PLOD3_PONAB;  
Q5U367, PLOD3_RAT;  Q20679, PLOD_CAEEL;  Q5UQC3, PLOD_MIMIV;  

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