ENZYME entry: EC 1.14.11.44

Accepted Name
(R)-dichlorprop dioxygenase (2-oxoglutarate).
Alternative Name(s)
(R)-mecoprop dioxygenase.
(R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase.
2-oxoglutarate-dependent (R)-dichlorprop dioxygenase.
2-oxoglutarate-dependent (R)-mecoprop dioxygenase.
Alpha-ketoglutarate-dependent (R)-dichlorprop dioxygenase.
Reaction catalysed
  • (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O(2) <=> 4-chloro-2-methylphenol + pyruvate + succinate + CO(2)
  • (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O(2) <=> 2,4-dichlorophenol + pyruvate + succinate + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop.
Cross-references
BRENDA1.14.11.44
EC2PDB1.14.11.44
ExplorEnz1.14.11.44
PRIAM enzyme-specific profiles1.14.11.44
KEGG Ligand Database for Enzyme Nomenclature1.14.11.44
IUBMB Enzyme Nomenclature1.14.11.44
IntEnz1.14.11.44
MEDLINEFind literature relating to 1.14.11.44
MetaCyc1.14.11.44
UniProtKB/Swiss-Prot
P83310, RDPA_DELAC;  Q8KSC8, RDPA_SPHHM;  

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