ENZYME entry: EC 1.14.11.51
Accepted Name | |||||||
---|---|---|---|---|---|---|---|
DNA N(6)-methyladenine demethylase | |||||||
Reaction catalysed | |||||||
2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate | |||||||
Comment(s) | |||||||
Catalyzes oxidative demethylation of DNA N(6)-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome. | |||||||
Cross-references | |||||||
BRENDA | 1.14.11.51 | ||||||
EC2PDB | 1.14.11.51 | ||||||
ExplorEnz | 1.14.11.51 | ||||||
PRIAM enzyme-specific profiles | 1.14.11.51 | ||||||
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.51 | ||||||
IUBMB Enzyme Nomenclature | 1.14.11.51 | ||||||
IntEnz | 1.14.11.51 | ||||||
MEDLINE | Find literature relating to 1.14.11.51 | ||||||
MetaCyc | 1.14.11.51 | ||||||
Rhea expert-curated reactions | 1.14.11.51 | ||||||
UniProtKB/Swiss-Prot |
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