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ENZYME

ENZYME entry: EC 1.14.11.79

Accepted Name
protein-L-histidine (3S)-3-hydroxylase
Alternative Name(s)
protein histidyl hydroxylase
Reaction catalysed
2-oxoglutarate + L-histidyl-[protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate
Comment(s)
  • The human enzymes encoded by the RIOX1 and RIOX2 genes catalyze the hydroxylation of L-histidine residues in the 60S ribosomal proteins Rpl8 and L27a, respectively.
  • Both proteins contain JmjC and winged helix domains, and both also catalyze histone L-lysine demethylation activities.
Cross-references
BRENDA1.14.11.79
EC2PDB1.14.11.79
ExplorEnz1.14.11.79
PRIAM enzyme-specific profiles1.14.11.79
KEGG Ligand Database for Enzyme Nomenclature1.14.11.79
IUBMB Enzyme Nomenclature1.14.11.79
IntEnz1.14.11.79
MEDLINEFind literature relating to 1.14.11.79
MetaCyc1.14.11.79
Rhea expert-curated reactions1.14.11.79
UniProtKB/Swiss-Prot
A5PK74, RIOX1_BOVINQ5ZMM1, RIOX1_CHICKA3KP59, RIOX1_DANRE
Q9H6W3, RIOX1_HUMANQ9JJF3, RIOX1_MOUSED3ZU57, RIOX1_RAT
Q5EA24, RIOX2_BOVINQ8IUF8, RIOX2_HUMANQ8CD15, RIOX2_MOUSE
Q5R673, RIOX2_PONABQ8CFC1, RIOX2_RAT

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