ENZYME

ENZYME entry: EC 1.14.11.n2

Accepted Name

Methylcytosine dioxygenase.

Reaction catalysed

DNA 5-methylcytosine + 2-oxoglutarate + O(2) <=> DNA 5-hydroxymethylcytosine + succinate + CO(2)

Comment(s)

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).
Might initiate a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system.
Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation.

Cross-references

UniProtKB/Swiss-Prot

Q8NFU7, TET1_HUMAN;	Q3URK3, TET1_MOUSE;	Q6N021, TET2_HUMAN;
Q4JK59, TET2_MOUSE;	O43151, TET3_HUMAN;	Q8BG87, TET3_MOUSE;

Back to the Top