ENZYME entry: EC 1.14.12.18
| Accepted Name |
|---|
| Biphenyl 2,3-dioxygenase.
|
| Alternative Name(s) |
|---|
| Biphenyl dioxygenase. |
| Reaction catalysed |
|---|
| Biphenyl + NADH + O(2) <=> (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) |
| Cofactor(s) |
|---|
| Iron.
|
| Comment(s) |
|---|
- The enzyme from Burkholderia fungorum strain LB400 (previously
Pseudomonas sp.) is part of a multicomponent system composed of an
NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type
ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske-
type iron-sulfur cluster and a catalytic mononuclear nonheme iron
center.
- Chlorine-substituted biphenyls can also act as substrates.
- Similar to the three-component enzyme systems EC 1.14.12.3 and
EC 1.14.12.11.
|
| Cross-references |
|---|
| PROSITE | PDOC00493 |
| BRENDA | 1.14.12.18 |
| EC2PDB | 1.14.12.18 |
| ExplorEnz | 1.14.12.18 |
| PRIAM enzyme-specific profiles | 1.14.12.18 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.12.18 |
| IUBMB Enzyme Nomenclature | 1.14.12.18 |
| IntEnz | 1.14.12.18 |
| MEDLINE | Find literature relating to 1.14.12.18 |
| MetaCyc | 1.14.12.18 |
| UniProtKB/Swiss-Prot |
|
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