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ENZYME entry: EC 1.14.12.18

Accepted Name
Biphenyl 2,3-dioxygenase.
Alternative Name(s)
Biphenyl dioxygenase.
Reaction catalysed
Biphenyl + NADH + O(2) <=> (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)
Cofactor(s)
Fe cation.
Comment(s)
  • The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center.
  • Chlorine-substituted biphenyls can also act as substrates.
  • Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.
Cross-references
PROSITEPDOC00493
BRENDA1.14.12.18
EC2PDB1.14.12.18
ExplorEnz1.14.12.18
PRIAM enzyme-specific profiles1.14.12.18
KEGG Ligand Database for Enzyme Nomenclature1.14.12.18
IUBMB Enzyme Nomenclature1.14.12.18
IntEnz1.14.12.18
MEDLINEFind literature relating to 1.14.12.18
MetaCyc1.14.12.18
UniProtKB/Swiss-Prot
Q52438, BPHA1_PSES1;  Q53122, BPHA1_RHOJR;  Q52439, BPHA2_PSES1;  
Q53123, BPHA2_RHOJR;  Q46372, BPHA_COMTE;  P37333, BPHA_PARXL;  
Q52028, BPHA_PSEPS;  Q46373, BPHE_COMTE;  P37334, BPHE_PARXL;  

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