ID   1.14.12.22
DE   carbazole 1,9a-dioxygenase.
AN   CARDO.
CA   (1) 9H-carbazole + H(+) + NADH + O2 = 2'-aminobiphenyl-2,3-diol + NAD(+).
CA   (2) 9H-carbazole + H(+) + NADPH + O2 = 2'-aminobiphenyl-2,3-diol +
CA   NADP(+).
CC   -!- This enzyme catalyzes the first reaction in the pathway of carbazole
CC       degradation.
CC   -!- The enzyme attacks at the 1 and 9a positions of carbazole, resulting
CC       in the formation of a highly unstable hemiaminal intermediate that
CC       undergoes a spontaneous cleavage and rearomatization, resulting in
CC       2'-aminobiphenyl-2,3-diol.
CC   -!- In most bacteria the enzyme is a complex composed of a terminal
CC       oxygenase, a ferredoxin, and a ferredoxin reductase.
CC   -!- The terminal oxygenase component contains a nonheme iron center and a
CC       Rieske [2Fe-2S] iron-sulfur cluster.
DR   Q8G8B6, CARAA_PSERE;  D5IGG0, CARAA_SPHSX;
//