ENZYME entry: EC 1.14.13.100
| Accepted Name |
|---|
| 25-hydroxycholesterol 7-alpha-hydroxylase.
|
| Alternative Name(s) |
|---|
| 25-hydroxycholesterol 7-alpha-monooxygenase. |
| Reaction catalysed |
|---|
- Cholest-5-ene-3-beta,25-diol + NADPH + O(2) <=> cholest-5-ene-3-beta,7-alpha,25-triol + NADP(+) + H(2)O
- Cholest-5-ene-3-beta,27-diol + NADPH + O(2) <=> cholest-5-ene-3-beta,7-alpha,27-triol + NADP(+) + H(2)O
|
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
| Unlike EC 1.14.13.99 which is specific for its oxysterol substrate,
this enzyme can also metabolize the oxysterols 24,25-
epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol,
but to a lesser extent.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.13.100 |
| EC2PDB | 1.14.13.100 |
| ExplorEnz | 1.14.13.100 |
| PRIAM enzyme-specific profiles | 1.14.13.100 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.100 |
| IUBMB Enzyme Nomenclature | 1.14.13.100 |
| IntEnz | 1.14.13.100 |
| MEDLINE | Find literature relating to 1.14.13.100 |
| MetaCyc | 1.14.13.100 |
| UniProtKB/Swiss-Prot |
|
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