ID   1.14.13.101
DE   senecionine N-oxygenase.
AN   senecionine monooxygenase (N-oxide-forming).
CA   NADPH + O2 + senecionine = H2O + NADP(+) + senecionine N-oxide.
CC   -!- NADH cannot replace NADPH.
CC   -!- While pyrrolizidine alkaloids of the senecionine and monocrotaline
CC       types are generally good substrates (e.g. senecionine, retrorsine and
CC       monocrotaline), the enzyme does not use ester alkaloids lacking an
CC       hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-
CC       alkaloids (e.g. sarracine) or unesterified necine bases (e.g.
CC       senkirkine) as substrates.
CC   -!- Senecionine N-oxide is used by insects as a chemical defense: it is
CC       non-toxic, but it is bioactivated to a toxic form by the action of
CC       cytochrome P450 oxidase when absorbed by insectivores.
DR   Q8MP06, SNO1_TYRJA ;
//