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ENZYME entry: EC 1.14.13.104

Accepted Name
(+)-menthofuran synthase.
Alternative Name(s)
(+)-MFS.
(+)-pulegone 9-hydroxylase.
Menthofuran synthase.
Reaction catalysed
(+)-pulegone + NADPH + O(2) <=> (+)-menthofuran + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan.
  • This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalyzed by EC 1.14.13.47.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.104
EC2PDB1.14.13.104
ExplorEnz1.14.13.104
PRIAM enzyme-specific profiles1.14.13.104
KEGG Ligand Database for Enzyme Nomenclature1.14.13.104
IUBMB Enzyme Nomenclature1.14.13.104
IntEnz1.14.13.104
MEDLINEFind literature relating to 1.14.13.104
MetaCyc1.14.13.104
UniProtKB/Swiss-Prot
Q947B7, MFS_MENPI

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