ENZYME entry: EC 1.14.13.106
| Accepted Name |
|---|
| Epi-isozizaene 5-monooxygenase.
|
| Alternative Name(s) |
|---|
| CYP170A1. |
| Reaction catalysed |
|---|
| (+)-epi-isozizaene + 2 NADPH + 2 O(2) <=> albaflavenone + 2 NADP(+) + 3 H(2)O |
| Comment(s) |
|---|
- This enzyme, from the soil-dwelling bacterium Streptomyces coelicolor
A3(2), catalyzes two sequential allylic oxidation reactions.
- The substrate epi-isozizaene, which is formed by the action of
EC 4.2.3.37 is first oxidized to yield the epimeric intermediates
(5R)-albaflavenol and (5S)-albaflavenol, which can be further
oxidized to yield the sesquiterpenoid antibiotic albaflavenone.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.106 |
| EC2PDB | 1.14.13.106 |
| ExplorEnz | 1.14.13.106 |
| PRIAM enzyme-specific profiles | 1.14.13.106 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.106 |
| IUBMB Enzyme Nomenclature | 1.14.13.106 |
| IntEnz | 1.14.13.106 |
| MEDLINE | Find literature relating to 1.14.13.106 |
| MetaCyc | 1.14.13.106 |
| UniProtKB/Swiss-Prot |
|
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