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ENZYME entry: EC 1.14.13.111

Accepted Name
Methanesulfonate monooxygenase (NADH).
Alternative Name(s)
Mesylate monooxygenase.
Methanesulfonic acid monooxygenase.
MSA monooxygenase.
MSAMO.
Reaction catalysed
Methanesulfonate + NADH + O(2) <=> formaldehyde + NAD(+) + sulfite + H(2)O
Cofactor(s)
Flavoprotein; Iron-sulfur.
Comment(s)
  • Methanesulfonate is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms.
  • Compared with EC 1.14.14.5, this enzyme has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methanesulfonate to butanesulfonate) and excludes all larger molecules, such as arylsulfonates.
  • The enzyme from the bacterium Methylosulfonomonas methylovora is a multicomponent system comprising an hydroxylase, a reductase (MsmD) and a ferredoxin (MsmC).
  • The hydroxylase has both large (MsmA) and small (MsmB) subunits, with each large subunit containing a Rieske-type [2Fe-2S] cluster.
  • Formerly EC 1.14.14.6.
Cross-references
BRENDA1.14.13.111
EC2PDB1.14.13.111
ExplorEnz1.14.13.111
PRIAM enzyme-specific profiles1.14.13.111
KEGG Ligand Database for Enzyme Nomenclature1.14.13.111
IUBMB Enzyme Nomenclature1.14.13.111
IntEnz1.14.13.111
MEDLINEFind literature relating to 1.14.13.111
MetaCyc1.14.13.111
UniProtKB/Swiss-Prot
Q9X404, MSMA_METHY;  Q9X405, MSMB_METHY;  P70752, MSMC_METHY;  
Q9X406, MSMD_METHY;  

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