ENZYME entry: EC 1.14.13.120

Accepted Name
Costunolide synthase.
Reaction catalysed
Germacra-1(10),4,11(13)-trien-12-oate + NADPH + O(2) <=> (+)-costunolide + NADP(+) + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien- 12-oate to give 6-alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which probably spontaneously cyclises to form the lactone ring.
Cross-references
BRENDA1.14.13.120
EC2PDB1.14.13.120
ExplorEnz1.14.13.120
PRIAM enzyme-specific profiles1.14.13.120
KEGG Ligand Database for Enzyme Nomenclature1.14.13.120
IUBMB Enzyme Nomenclature1.14.13.120
IntEnz1.14.13.120
MEDLINEFind literature relating to 1.14.13.120
MetaCyc1.14.13.120
UniProtKB/Swiss-Prot
F8S1I0, C7BL2_LACSA;  G3GBK0, C7BL3_CICIN;  

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