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ENZYME entry: EC 1.14.13.125

Accepted Name
Tryptophan N-monooxygenase.
Alternative Name(s)
CYP79B1.
CYP79B2.
CYP79B3.
Tryptophan N-hydroxylase.
Reaction catalysed
L-tryptophan + 2 NADPH + 2 O(2) <=> indole-3-acetaldoxime + 2 NADP(+) + 3 H(2)O + CO(2)
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This enzyme catalyzes two successive N-hydroxylations of L-tryptophan, the first steps in the biosynthesis of the both auxin and the indole alkaloid phytoalexin camalexin.
  • The product of the two hydroxylations, N,N-dihydroxy-L-tryptophan, is extremely labile and dehydrates spontaneously.
  • The dehydrated product is then subject to a decarboxylation that produces the oxime.
  • It is still not known whether the decarboxylation is spontaneous or catalyzed by the enzyme.
  • The product, (E)-indol-3-ylacetaldoxime, undergoes a spontaneous isomerization to the (Z) form.
  • Formerly EC 1.14.13.n2.
Cross-references
BRENDA1.14.13.125
EC2PDB1.14.13.125
ExplorEnz1.14.13.125
PRIAM enzyme-specific profiles1.14.13.125
KEGG Ligand Database for Enzyme Nomenclature1.14.13.125
IUBMB Enzyme Nomenclature1.14.13.125
IntEnz1.14.13.125
MEDLINEFind literature relating to 1.14.13.125
MetaCyc1.14.13.125
UniProtKB/Swiss-Prot
O81346, C79B2_ARATH;  Q501D8, C79B3_ARATH;  

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