ENZYME entry: EC 1.14.13.132

Accepted Name
Squalene monooxygenase.
Alternative Name(s)
Squalene epoxidase.
Reaction catalysed
Squalene + NADPH + O(2) <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP(+) + H(2)O
Cofactor(s)
FAD.
Comment(s)
  • This enzyme, together with EC 5.4.99.7, was formerly known as squalene oxidocyclase.
  • The electron donor, NADPH, is coupled via EC 1.6.2.4.
  • Formerly EC 1.14.1.3, EC 1.14.99.7 and EC 1.99.1.13.
Cross-references
BRENDA1.14.13.132
EC2PDB1.14.13.132
ExplorEnz1.14.13.132
PRIAM enzyme-specific profiles1.14.13.132
KEGG Ligand Database for Enzyme Nomenclature1.14.13.132
IUBMB Enzyme Nomenclature1.14.13.132
IntEnz1.14.13.132
MEDLINEFind literature relating to 1.14.13.132
MetaCyc1.14.13.132
UniProtKB/Swiss-Prot
O65404, ERG11_ARATH;  O65727, ERG11_BRANA;  O65402, ERG12_ARATH;  
O65726, ERG12_BRANA;  O65403, ERG13_ARATH;  Q9SM02, ERG14_ARATH;  
O81000, ERG15_ARATH;  Q8VYH2, ERG16_ARATH;  Q75F69, ERG1_ASHGO;  
Q92206, ERG1_CANAL;  O13306, ERG1_CANGA;  Q14534, ERG1_HUMAN;  
P52019, ERG1_MOUSE;  O48651, ERG1_PANGI;  P52020, ERG1_RAT;  
Q9C1W3, ERG1_SCHPO;  P32476, ERG1_YEAST;  

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