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ENZYME entry: EC 1.14.13.148

Accepted Name
Trimethylamine monooxygenase.
Alternative Name(s)
Flavin-containing monooxygenase 3.
Reaction catalysed
N,N,N-trimethylamine + NADPH + O(2) <=> N,N,N-trimethylamine N-oxide + NADP(+) + H(2)O
Cofactor(s)
Flavoprotein.
Comment(s)
  • The bacterial enzyme enables bacteria to use trimethylamine as the sole source of carbon and energy.
  • The mammalian enzyme is involved in detoxification of trimethylamine.
  • Mutations in the human enzyme cause the inheritable disease known as trimethylaminuria (fish odor syndrome).
Cross-references
BRENDA1.14.13.148
EC2PDB1.14.13.148
ExplorEnz1.14.13.148
PRIAM enzyme-specific profiles1.14.13.148
KEGG Ligand Database for Enzyme Nomenclature1.14.13.148
IUBMB Enzyme Nomenclature1.14.13.148
IntEnz1.14.13.148
MEDLINEFind literature relating to 1.14.13.148
MetaCyc1.14.13.148
UniProtKB/Swiss-Prot
Q8HYJ9, FMO3_BOVIN;  Q95LA1, FMO3_CANLF;  P31513, FMO3_HUMAN;  
Q8SPQ7, FMO3_MACMU;  P97501, FMO3_MOUSE;  Q7YS44, FMO3_PANTR;  
P32417, FMO3_RABIT;  Q9EQ76, FMO3_RAT;  

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