ENZYME entry: EC 1.14.13.157

Accepted Name
1,8-cineole 2-exo-monooxygenase.
Alternative Name(s)
CYP3A4.
Reaction catalysed
1,8-cineole + NADPH + O(2) <=> 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including stereoids, fatty acids, and xenobiotics.
  • Cf. EC 1.14.13.97, EC 1.14.13.67 and EC 1.14.13.32.
Cross-references
BRENDA1.14.13.157
EC2PDB1.14.13.157
ExplorEnz1.14.13.157
PRIAM enzyme-specific profiles1.14.13.157
KEGG Ligand Database for Enzyme Nomenclature1.14.13.157
IUBMB Enzyme Nomenclature1.14.13.157
IntEnz1.14.13.157
MEDLINEFind literature relating to 1.14.13.157
MetaCyc1.14.13.157
UniProtKB/Swiss-Prot
P08684, CP3A4_HUMAN

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