ENZYME entry: EC 1.14.13.165

Accepted Name
Nitric-oxide synthase (NAD(P)H-dependent).
Alternative Name(s)
Nitric oxide synthetase.
NO synthase.
Reaction catalysed
2 L-arginine + 3 NAD(P)H + 4 O(2) <=> 2 L-citrulline + 2 nitric oxide + 3 NAD(P)(+) + 4 H(2)O
Cofactor(s)
5,6,7,8-tetrahydrobiopterin; Ferriprotoporphyrin IX.
Comment(s)
  • Most of the bacterial and archaeal enzymes consist of only an oxidase domain and function together with bacterial ferredoxins.
  • The enzyme from the delta-proteobacterium Sorangium cellulosum also includes a reductase domain that binds FAD, FMN and a [2Fe-2S] cluster.
  • The similar enzymes from plants and animals use only NADPH as acceptor (cf. EC 1.14.13.39).
Cross-references
BRENDA1.14.13.165
EC2PDB1.14.13.165
ExplorEnz1.14.13.165
PRIAM enzyme-specific profiles1.14.13.165
KEGG Ligand Database for Enzyme Nomenclature1.14.13.165
IUBMB Enzyme Nomenclature1.14.13.165
IntEnz1.14.13.165
MEDLINEFind literature relating to 1.14.13.165
MetaCyc1.14.13.165
UniProtKB/Swiss-Prot
O34453, NOSO_BACSU;  Q9RR97, NOSO_DEIRA;  Q5HEK7, NOSO_STAAC;  
P0A092, NOSO_STAAM;  P0A093, NOSO_STAAN;  Q6GFE2, NOSO_STAAR;  
Q6G818, NOSO_STAAS;  P0A004, NOSO_STAAU;  P0A094, NOSO_STAAW;  

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