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ENZYME entry: EC 1.14.13.178

Accepted Name
Methylxanthine N(1)-demethylase.
Reaction catalysed
  • Caffeine + O(2) + NAD(P)H <=> theobromine + NAD(P)(+) + H(2)O + formaldehyde
  • Theophylline + O(2) + NAD(P)H <=> 3-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde
  • Paraxanthine + O(2) + NAD(P)H <=> 7-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde
Cofactor(s)
Fe cation.
Comment(s)
  • The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, and has a 5-fold higher activity with NADH than with NADPH.
  • Also demethylate 1-methylxantine with lower efficiency.
  • Forms part of the degradation pathway of methylxanthines.
Cross-references
BRENDA1.14.13.178
EC2PDB1.14.13.178
ExplorEnz1.14.13.178
PRIAM enzyme-specific profiles1.14.13.178
KEGG Ligand Database for Enzyme Nomenclature1.14.13.178
IUBMB Enzyme Nomenclature1.14.13.178
IntEnz1.14.13.178
MEDLINEFind literature relating to 1.14.13.178
MetaCyc1.14.13.178
UniProtKB/Swiss-Prot
H9N289, NDMA_PSEPU

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