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ENZYME entry: EC

Accepted Name
Methylxanthine N(1)-demethylase.
Reaction catalysed
  • Caffeine + O(2) + NAD(P)H <=> theobromine + NAD(P)(+) + H(2)O + formaldehyde
  • Theophylline + O(2) + NAD(P)H <=> 3-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde
  • Paraxanthine + O(2) + NAD(P)H <=> 7-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde
Fe cation.
  • The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC, and has a 5-fold higher activity with NADH than with NADPH.
  • Also demethylate 1-methylxantine with lower efficiency.
  • Forms part of the degradation pathway of methylxanthines.
PRIAM enzyme-specific profiles1.14.13.178
KEGG Ligand Database for Enzyme Nomenclature1.14.13.178
IUBMB Enzyme Nomenclature1.14.13.178
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