ID   1.14.13.178
DE   methylxanthine N(1)-demethylase.
CA   (1) caffeine + NADH + O2 + H(+) = theobromine + formaldehyde + NAD(+) +
CA   H2O.
CA   (2) caffeine + NADPH + O2 + H(+) = theobromine + formaldehyde + NADP(+) +
CA   H2O.
CA   (3) theophylline + NADPH + O2 + H(+) = 3-methylxanthine + formaldehyde +
CA   NADP(+) + H2O.
CA   (4) theophylline + NADH + O2 + H(+) = 3-methylxanthine + formaldehyde +
CA   NAD(+) + H2O.
CA   (5) 1,7-dimethylxanthine + NADH + O2 + H(+) = 7-methylxanthine +
CA   formaldehyde + NAD(+) + H2O.
CA   (6) 1,7-dimethylxanthine + NADPH + O2 + H(+) = 7-methylxanthine +
CA   formaldehyde + NADP(+) + H2O.
CC   -!- The enzyme from the bacterium Pseudomonas putida shares an
CC       NAD(P)H-FMN reductase subunit with EC 1.14.13.179, and has a 5-fold
CC       higher activity with NADH than with NADPH.
CC   -!- Also demethylates 1-methylxantine with lower efficiency.
CC   -!- Forms part of the degradation pathway of methylxanthines.
DR   H9N289, NDMA_PSEPU ;
//