ENZYME entry: EC 1.14.13.179

Accepted Name
Methylxanthine N(3)-demethylase.
Reaction catalysed
  • Theobromine + O(2) + NAD(P)H <=> 7-methylxanthine + NAD(P)(+) + H(2)O + formaldehyde
  • 3-methylxanthine + O(2) + NAD(P)H <=> xanthine + NAD(P)(+) + H(2)O + formaldehyde
Cofactor(s)
Fe cation.
Comment(s)
  • The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, and has higher activity with NADH than with NADPH.
  • Also demethylates caffeine and theophylline with lower efficiency.
  • Forms part of the degradation pathway of methylxanthines.
Cross-references
BRENDA1.14.13.179
EC2PDB1.14.13.179
ExplorEnz1.14.13.179
PRIAM enzyme-specific profiles1.14.13.179
KEGG Ligand Database for Enzyme Nomenclature1.14.13.179
IUBMB Enzyme Nomenclature1.14.13.179
IntEnz1.14.13.179
MEDLINEFind literature relating to 1.14.13.179
MetaCyc1.14.13.179
UniProtKB/Swiss-Prot
H9N290, NDMB_PSEPU

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