ID   1.14.13.179
DE   methylxanthine N(3)-demethylase.
CA   (1) H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde +
CA   H2O + NAD(+).
CA   (2) H(+) + NADPH + O2 + theobromine = 7-methylxanthine + formaldehyde +
CA   H2O + NADP(+).
CA   (3) 3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) +
CA   xanthine.
CA   (4) 3-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) +
CA   xanthine.
CC   -!- The enzyme from the bacterium Pseudomonas putida shares an
CC       NAD(P)H-FMN reductase subunit with EC 1.14.13.178, and has higher
CC       activity with NADH than with NADPH.
CC   -!- Also demethylates caffeine and theophylline with lower efficiency.
CC   -!- Forms part of the degradation pathway of methylxanthines.
DR   H9N290, NDMB_PSEPU ;
//