ENZYME entry: EC 1.14.13.181

Accepted Name
13-deoxydaunorubicin hydroxylase.
Reaction catalysed
  • 13-deoxydaunorubicin + NADPH + O(2) <=> 13-dihydrodaunorubicin + NADP(+) + H(2)O
  • 13-dihydrodaunorubicin + NADPH + O(2) <=> daunorubicin + NADP(+) + 2 H(2)O
Comment(s)
The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogs (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position.
Cross-references
BRENDA1.14.13.181
EC2PDB1.14.13.181
ExplorEnz1.14.13.181
PRIAM enzyme-specific profiles1.14.13.181
KEGG Ligand Database for Enzyme Nomenclature1.14.13.181
IUBMB Enzyme Nomenclature1.14.13.181
IntEnz1.14.13.181
MEDLINEFind literature relating to 1.14.13.181
MetaCyc1.14.13.181
UniProtKB/Swiss-Prot
Q93MI2, DOXA_STRC0;  Q9ZAU3, DOXA_STRPE;  Q59971, DOXA_STRS5;  

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