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ENZYME entry: EC 1.14.13.185

Accepted Name
Pikromycin synthase.
Alternative Name(s)
CYP107L1.
Reaction catalysed
  • Narbomycin + NADPH + O(2) <=> pikromycin + NADP(+) + H(2)O
  • Narbomycin + NADPH + O(2) <=> neopikromycin + NADP(+) + H(2)O
  • Narbomycin + 2 NADPH + 2 O(2) <=> novapikromyin + 2 NADP(+) + 2 H(2)O
  • 10-deoxymethymycin + NADPH + O(2) <=> methymycin + NADP(+) + H(2)O
  • 10-deoxymethymycin + NADPH + O(2) <=> neomethymycin + NADP(+) + H(2)O
  • 10-deoxymethymycin + 2 NADPH + 2 O(2) <=> novamethymycin + 2 NADP(+) + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit.
  • With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin.
Cross-references
BRENDA1.14.13.185
EC2PDB1.14.13.185
ExplorEnz1.14.13.185
PRIAM enzyme-specific profiles1.14.13.185
KEGG Ligand Database for Enzyme Nomenclature1.14.13.185
IUBMB Enzyme Nomenclature1.14.13.185
IntEnz1.14.13.185
MEDLINEFind literature relating to 1.14.13.185
MetaCyc1.14.13.185
UniProtKB/Swiss-Prot
O87605, PIKC_STRVZ

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