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ENZYME entry: EC 1.14.13.190

Accepted Name
Ferruginol synthase.
Alternative Name(s)
CYP76AH1.
Miltiradiene oxidase.
Reaction catalysed
Abieta-8,11,13-triene + NADPH + O(2) <=> ferruginol + NADP(+) + H(2)O
Comment(s)
  • The enzyme is found in some members of the Lamiaceae (mint family).
  • The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.
Cross-references
BRENDA1.14.13.190
EC2PDB1.14.13.190
ExplorEnz1.14.13.190
PRIAM enzyme-specific profiles1.14.13.190
KEGG Ligand Database for Enzyme Nomenclature1.14.13.190
IUBMB Enzyme Nomenclature1.14.13.190
IntEnz1.14.13.190
MEDLINEFind literature relating to 1.14.13.190
MetaCyc1.14.13.190
UniProtKB/Swiss-Prot
S4UX02, CYPH1_SALMI

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