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ENZYME entry: EC 184.108.40.206
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|Nitric-oxide synthase (NADPH).
|Endothelium-derived relaxation factor-forming enzyme.|
|Endothelium-derived relaxing factor synthase.|
|2 L-arginine + 3 NADPH + 4 O(2) <=> 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O|
- The enzyme consists of linked oxygenase and reductase domains.
- The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX)
and tetrahydrobiopterin, and its two domains are linked via a
regulatory calmodulin-binding domain.
- Upon calcium-induced calmodulin binding, the reductase and oxygenase
domains form a complex, allowing electrons to flow from NADPH via FAD
and FMN to the active center.
- The reductase domain of the enzyme from the bacterium Sorangium
cellulosum utilizes a [2Fe-2S] cluster to transfer the electrons from
NADPH to the active center.
- Cf. EC 220.127.116.11.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
|Q66GP9, NOA1_ARATH; ||P29475, NOS1_HUMAN; ||Q9Z0J4, NOS1_MOUSE; |
|O19132, NOS1_RABIT; ||P29476, NOS1_RAT; ||Q29498, NOS1_SHEEP; |
|Q27995, NOS2_BOVIN; ||O62699, NOS2_CANLF; ||Q28314, NOS2_CAPHI; |
|Q92037, NOS2_CARAU; ||O54705, NOS2_CAVPO; ||Q90703, NOS2_CHICK; |
|P35228, NOS2_HUMAN; ||O46660, NOS2_MACMU; ||P29477, NOS2_MOUSE; |
|Q92091, NOS2_ONCMY; ||P79290, NOS2_PIG; ||O19114, NOS2_RABIT; |
|Q06518, NOS2_RAT; ||P29473, NOS3_BOVIN; ||Q9TUX8, NOS3_CANLF; |
|P97270, NOS3_CAVPO; ||P29474, NOS3_HUMAN; ||P70313, NOS3_MOUSE; |
|Q28969, NOS3_PIG; ||Q62600, NOS3_RAT; ||P79209, NOS3_SHEEP; |
|B1B557, NOSL_BOMMO; ||O61608, NOS_ANOST; ||Q8T8C0, NOS_BOMMO; |
|Q27571, NOS_DROME; ||O61309, NOS_LYMST; ||Q6YPG5, NOS_ORYSJ; |
|Q26240, NOS_RHOPR; ||Q9I9M2, NOS_SQUAC; |
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