ENZYME entry: EC 1.14.13.54

Accepted Name
Ketosteroid monooxygenase.
Alternative Name(s)
Steroid-ketone monooxygenase.
Reaction catalysed
Ketosteroid + NADPH + O(2) <=> steroid ester/lactone + NADP(+) + H(2)O Progesterone + NADPH + O(2) <=> testosterone acetate + NADP(+) + H(2)O Androstenedione + NADPH + O(2) <=> testololactone + NADP(+) + H(2)O 17-alpha-hydroxyprogesterone + NADPH + O(2) <=> androstenedione + NADP(+) + H(2)O + acetate
Cofactor(s)
FAD.
Comment(s)
A single FAD-containing enzyme catalyzes three types of monooxygenase (Baeyer-Villiger oxidation) reaction. The oxidative esterification of a number of derivatives of progesterone to produce the corresponding 17-alpha-hydroxysteroid 17-acetate ester, such as testosterone acetate, is shown in reaction (2). The oxidative lactonization of a number of derivatives of androstenedione to produce the 13,17-secoandrosteno-17,13-alpha- lactone, such as testololactone, is shown in reaction (3). The oxidative cleavage of the 17-beta-side-chain of 17-alpha- hydroxyprogesterone to produce androstenedione and acetate is shown in reaction (4). reaction (2) is also catalyzed by EC 1.14.99.4 and reactions (3) and (4) correspond to that catalyzed by EC 1.14.99.12. The possibility that a single enzyme is responsible for the reactions ascribed to EC 1.14.99.4 and EC 1.14.99.12 in other tissues cannot be excluded.
Cross-references
BRENDA	1.14.13.54
EC2PDB	1.14.13.54
ExplorEnz	1.14.13.54
PRIAM enzyme-specific profiles	1.14.13.54
KEGG Ligand Database for Enzyme Nomenclature	1.14.13.54
IUBMB Enzyme Nomenclature	1.14.13.54
IntEnz	1.14.13.54
MEDLINE	Find literature relating to 1.14.13.54
MetaCyc	1.14.13.54

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