ENZYME entry: EC 1.14.13.70

Accepted Name
Sterol 14-alpha-demethylase.
Alternative Name(s)
Cytochrome P450 51.
Lanosterol 14-alpha-demethylase.
Lanosterol 14-demethylase.
Obtusufoliol 14-demethylase.
Reaction catalysed
A 14-alpha-methylsteroid + 3 O(2) + 3 NADPH <=> a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This heme-thiolate (P450) enzyme acts on a range of steroids with a 14-alpha-methyl group, such as obtusifoliol and lanosterol.
  • The enzyme catalyzes two successive hydroxylations of the 14-alpha- methyl group, followed by elimination as formate, leaving a 14(15) double bond.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.70
EC2PDB1.14.13.70
ExplorEnz1.14.13.70
PRIAM enzyme-specific profiles1.14.13.70
KEGG Ligand Database for Enzyme Nomenclature1.14.13.70
IUBMB Enzyme Nomenclature1.14.13.70
IntEnz1.14.13.70
MEDLINEFind literature relating to 1.14.13.70
MetaCyc1.14.13.70
UniProtKB/Swiss-Prot
Q9SAA9, CP511_ARATH;  Q4PJW3, CP51A_BOVIN;  Q16850, CP51A_HUMAN;  
Q4R8S6, CP51A_MACFA;  Q8K0C4, CP51A_MOUSE;  O46420, CP51A_PIG;  
Q5RE72, CP51A_PONAB;  Q64654, CP51A_RAT;  Q759W0, CP51_ASHGO;  
P10613, CP51_CANAL;  P50859, CP51_CANGA;  P14263, CP51_CANTR;  
Q9UVC3, CP51_CUNEL;  Q1ZXH9, CP51_DICDI;  Q02315, CP51_ISSOR;  
Q5UQI3, CP51_MIMIV;  P0A513, CP51_MYCBO;  P9WPP8, CP51_MYCTO;  
P9WPP9, CP51_MYCTU;  Q5IZM4, CP51_MYCVP;  Q12664, CP51_PENIT;  
Q09736, CP51_SCHPO;  P93846, CP51_SORBI;  Q7Z1V1, CP51_TRYCC;  
O14442, CP51_UNCNE;  P49602, CP51_USTMA;  P93596, CP51_WHEAT;  
P10614, CP51_YEAST;  

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