ENZYME entry: EC 1.14.13.72

Accepted Name
Methylsterol monooxygenase.
Alternative Name(s)
4-methylsterol oxidase.
Methylsterol hydroxylase.
Reaction catalysed
  • 4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) <=> 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O
  • 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) <=> 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + 2 H(2)O
  • 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + O(2) <=> 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + H(2)O
Comment(s)
  • Requires cytochrome b5.
  • Also acts on 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol.
  • The sterol can be based on cycloartenol as well as lanosterol.
  • Formerly EC 1.14.99.16.
Cross-references
BRENDA1.14.13.72
EC2PDB1.14.13.72
ExplorEnz1.14.13.72
PRIAM enzyme-specific profiles1.14.13.72
KEGG Ligand Database for Enzyme Nomenclature1.14.13.72
IUBMB Enzyme Nomenclature1.14.13.72
IntEnz1.14.13.72
MEDLINEFind literature relating to 1.14.13.72
MetaCyc1.14.13.72
UniProtKB/Swiss-Prot
Q5ZLL6, MSMO1_CHICK;  Q7ZW77, MSMO1_DANRE;  Q15800, MSMO1_HUMAN;  
Q4R4Q4, MSMO1_MACFA;  Q9CRA4, MSMO1_MOUSE;  Q6UGB2, MSMO1_PIG;  
Q5R574, MSMO1_PONAB;  O35532, MSMO1_RAT;  Q55D52, MSMOA_DICDI;  
Q55D54, MSMOB_DICDI;  O59933, MSMO_CANAL;  Q9UUH4, MSMO_SCHPO;  
P53045, MSMO_YEAST;  Q8L7W5, SMO11_ARATH;  Q1EC69, SMO12_ARATH;  
F4JLZ6, SMO13_ARATH;  Q9ZW22, SMO21_ARATH;  Q8VWZ8, SMO22_ARATH;  

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