ENZYME entry: EC 1.14.13.76

Accepted Name
Taxane 10-beta-hydroxylase.
Alternative Name(s)
5-alpha-taxadienol-10-beta-hydroxylase.
Reaction catalysed
Taxa-4(20),11-dien-5-alpha-yl acetate + NADPH + O(2) <=> 10-beta-hydroxytaxa-4(20),11-dien-5-alpha-yl acetate + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
Involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.76
EC2PDB1.14.13.76
ExplorEnz1.14.13.76
PRIAM enzyme-specific profiles1.14.13.76
KEGG Ligand Database for Enzyme Nomenclature1.14.13.76
IUBMB Enzyme Nomenclature1.14.13.76
IntEnz1.14.13.76
MEDLINEFind literature relating to 1.14.13.76
MetaCyc1.14.13.76
UniProtKB/Swiss-Prot
Q9AXM6, T10H_TAXCU

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