ENZYME entry: EC 1.14.13.79
| Accepted Name |
|---|
| Ent-kaurenoic acid oxidase.
|
| Reaction catalysed |
|---|
- Ent-kaur-16-en-19-oate + NADPH + O(2) <=> ent-7-alpha-hydroxykaur-16-en-19-oate + NADP(+) + H(2)O
- Ent-7-alpha-hydroxykaur-16-en-19-oate + NADPH + O(2) <=> gibberellin A(12) aldehyde + NADP(+) + 2 H(2)O
- Gibberellin A(12) aldehyde + NADPH + O(2) <=> gibberellin A(12) + NADP(+) + H(2)O
|
| Comment(s) |
|---|
- Requires cytochrome P450.
- Catalyzes three sucessive oxidations of ent-kaurenoic acid.
- The second step includes a ring-B contraction giving the gibbane
skeleton.
- In Cucurbita maxima, ent-6-alpha,7-alpha-dihydroxykaur-16-en-19-oate
is also formed.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.13.79 |
| EC2PDB | 1.14.13.79 |
| ExplorEnz | 1.14.13.79 |
| PRIAM enzyme-specific profiles | 1.14.13.79 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.79 |
| IUBMB Enzyme Nomenclature | 1.14.13.79 |
| IntEnz | 1.14.13.79 |
| MEDLINE | Find literature relating to 1.14.13.79 |
| MetaCyc | 1.14.13.79 |
| UniProtKB/Swiss-Prot |
|
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