ID   1.14.13.8
DE   flavin-containing monooxygenase.
AN   dimethylaniline monooxygenase (N-oxide-forming).
AN   dimethylaniline N-oxidase.
AN   dimethylaniline oxidase.
AN   DMA oxidase.
AN   FAD-containing monooxygenase.
AN   flavin mixed function oxidase.
AN   flavin monooxygenase.
AN   FMO.
AN   methylphenyltetrahydropyridine N-monooxygenase.
AN   mixed-function amine oxidase.
AN   N,N-dimethylaniline monooxygenase.
AN   Ziegler's enzyme.
CA   H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline
CA   N-oxide + NADP(+).
CC   -!- A broad spectrum monooxygenase that accepts substrates as diverse as
CC       hydrazines, phosphines, boron-containing compounds, sulfides,
CC       selenides, iodide, as well as primary, secondary and tertiary amines.
CC   -!- Is distinct from other monooxygenases in that the enzyme forms a
CC       relatively stable hydroperoxy flavin intermediate.
CC   -!- Generally converts nucleophilic heteroatom-containing chemicals and
CC       drugs into harmless, readily excreted metabolites.
CC   -!- For example, N-oxygenation is largely responsible for the
CC       detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl-
CC       1,2,3,6-tetrahydropyridine (MPTP).
CC   -!- Formerly EC 1.13.12.11.
DR   Q95LA2, FMO1_CANLF ;  Q01740, FMO1_HUMAN ;  P50285, FMO1_MOUSE ;
DR   P16549, FMO1_PIG   ;  P17636, FMO1_RABIT ;  P36365, FMO1_RAT   ;
DR   Q28505, FMO2_MACMU ;  P17635, FMO2_RABIT ;  Q8HYJ9, FMO3_BOVIN ;
DR   Q95LA1, FMO3_CANLF ;  P49328, FMO3_CAVPO ;  P31513, FMO3_HUMAN ;
DR   Q8SPQ7, FMO3_MACMU ;  P97501, FMO3_MOUSE ;  Q7YS44, FMO3_PANTR ;
DR   P32417, FMO3_RABIT ;  Q9EQ76, FMO3_RAT   ;  P31512, FMO4_HUMAN ;
DR   Q8VHG0, FMO4_MOUSE ;  P36367, FMO4_RABIT ;  Q8K4B7, FMO4_RAT   ;
DR   P49109, FMO5_CAVPO ;  P49326, FMO5_HUMAN ;  P97872, FMO5_MOUSE ;
DR   Q04799, FMO5_RABIT ;  Q8K4C0, FMO5_RAT   ;  O60774, FMO6_HUMAN ;
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