ENZYME entry: EC 1.14.13.80

Accepted Name
(R)-limonene 6-monooxygenase.
Alternative Name(s)
(+)-limonene 6-monooxygenase.
(+)-limonene-6-hydroxylase.
Reaction catalysed
(+)-(R)-limonene + NADPH + O(2) <=> (+)-trans-carveol + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The reaction is stereospecific with over 95% yield of (+)-trans- carveol from (R)-limonene.
  • (S)-Limonene, the substrate for EC 1.14.13.48 is not a substrate.
  • Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.80
EC2PDB1.14.13.80
ExplorEnz1.14.13.80
PRIAM enzyme-specific profiles1.14.13.80
KEGG Ligand Database for Enzyme Nomenclature1.14.13.80
IUBMB Enzyme Nomenclature1.14.13.80
IntEnz1.14.13.80
MEDLINEFind literature relating to 1.14.13.80
MetaCyc1.14.13.80
UniProtKB/Swiss-Prot
P11712, CP2C9_HUMAN;  P33261, CP2CJ_HUMAN;  

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