Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 1.14.13.88

Accepted Name
Flavonoid 3',5'-hydroxylase.
Alternative Name(s)
F3',5'H.
F3'5'H.
Reaction catalysed
A flavanone + 2 NADPH + 2 O(2) <=> a 3',5'-dihydroxyflavanone + 2 NADP(+) + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone.
  • In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin).
  • The enzyme catalyzes the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin).
  • The enzyme also catalyzes the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin.
  • NADH is not a good substitute for NADPH.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.88
EC2PDB1.14.13.88
ExplorEnz1.14.13.88
PRIAM enzyme-specific profiles1.14.13.88
KEGG Ligand Database for Enzyme Nomenclature1.14.13.88
IUBMB Enzyme Nomenclature1.14.13.88
IntEnz1.14.13.88
MEDLINEFind literature relating to 1.14.13.88
MetaCyc1.14.13.88
UniProtKB/Swiss-Prot
P48418, C75A1_PETHY;  P37120, C75A2_SOLME;  P48419, C75A3_PETHY;  
Q96581, C75A4_GENTR;  Q96418, C75A5_EUSER;  O04773, C75A6_CAMME;  
O04790, C75A7_EUSER;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-