ENZYME entry: EC 1.14.13.89

Accepted Name
Isoflavone 2'-hydroxylase.
Alternative Name(s)
CYP Ge-3.
CYP81E1.
Isoflavone 2'-monooxygenase.
Reaction catalysed
An isoflavone + NADPH + O(2) <=> a 2'-hydroxyisoflavone + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Acts on daidzein, formononetin and genistein.
  • EC 1.14.13.53 has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.89
EC2PDB1.14.13.89
ExplorEnz1.14.13.89
PRIAM enzyme-specific profiles1.14.13.89
KEGG Ligand Database for Enzyme Nomenclature1.14.13.89
IUBMB Enzyme Nomenclature1.14.13.89
IntEnz1.14.13.89
MEDLINEFind literature relating to 1.14.13.89
MetaCyc1.14.13.89
UniProtKB/Swiss-Prot
P93147, C81E1_GLYEC

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