ENZYME entry: EC 1.14.13.97

Accepted Name
Taurochenodeoxycholate 6-alpha-hydroxylase.
Alternative Name(s)
Taurochenodeoxycholate 6-alpha-monooxygenase.
Reaction catalysed
  • Taurochenodeoxycholate + NADPH + O(2) <=> taurohyocholate + NADP(+) + H(2)O
  • Lithocholate + NADPH + O(2) <=> hyodeoxycholate + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Requires cytochrome b5 for maximal activity.
  • Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate.
  • In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.97
EC2PDB1.14.13.97
ExplorEnz1.14.13.97
PRIAM enzyme-specific profiles1.14.13.97
KEGG Ligand Database for Enzyme Nomenclature1.14.13.97
IUBMB Enzyme Nomenclature1.14.13.97
IntEnz1.14.13.97
MEDLINEFind literature relating to 1.14.13.97
MetaCyc1.14.13.97
UniProtKB/Swiss-Prot
P08684, CP3A4_HUMAN;  Q9GJX5, CP4AL_PIG;  

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