ENZYME entry: EC 1.14.13.97
| Accepted Name |
|---|
| Taurochenodeoxycholate 6-alpha-hydroxylase.
|
| Alternative Name(s) |
|---|
| Taurochenodeoxycholate 6-alpha-monooxygenase. |
| Reaction catalysed |
|---|
- Taurochenodeoxycholate + NADPH + O(2) <=> taurohyocholate + NADP(+) + H(2)O
- Lithocholate + NADPH + O(2) <=> hyodeoxycholate + NADP(+) + H(2)O
|
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- Requires cytochrome b5 for maximal activity.
- Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on
lithocholate and chenodeoxycholate.
- In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a
primary bile acid.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.13.97 |
| EC2PDB | 1.14.13.97 |
| ExplorEnz | 1.14.13.97 |
| PRIAM enzyme-specific profiles | 1.14.13.97 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.97 |
| IUBMB Enzyme Nomenclature | 1.14.13.97 |
| IntEnz | 1.14.13.97 |
| MEDLINE | Find literature relating to 1.14.13.97 |
| MetaCyc | 1.14.13.97 |
| UniProtKB/Swiss-Prot |
|
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