ID   1.14.13.97
DE   Taurochenodeoxycholate 6-alpha-hydroxylase.
AN   Taurochenodeoxycholate 6-alpha-monooxygenase.
CA   (1) Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) +
CA   H(2)O.
CA   (2) Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O.
CF   Heme-thiolate.
CC   -!- Requires cytochrome b5 for maximal activity.
CC   -!- Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on
CC       lithocholate and chenodeoxycholate.
CC   -!- In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a
CC       primary bile acid.
PR   PROSITE; PDOC00081;
DR   P08684, CP3A4_HUMAN;  Q9GJX5, CP4AL_PIG  ;
//