ENZYME entry: EC 1.14.13.98
| Accepted Name |
|---|
| Cholesterol 24-hydroxylase.
|
| Alternative Name(s) |
|---|
| Cholesterol 24-monooxygenase. |
| Cholesterol 24S-hydroxylase. |
| Cytochrome P450 46A1. |
| Reaction catalysed |
|---|
| Cholesterol + NADPH + O(2) <=> (24S)-24-hydroxycholesterol + NADP(+) + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- Can also produce 25-hydroxycholesterol.
- In addition, it can further hydroxylate the product to 24,25-
dihydroxycholesterol and 24,27-dihydroxycholesterol.
- This reaction is the first step in the enzymatic degradation of
cholesterol in the brain as hydroxycholesterol can pass the blood-
brain barrier whereas cholesterol cannot.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.13.98 |
| EC2PDB | 1.14.13.98 |
| ExplorEnz | 1.14.13.98 |
| PRIAM enzyme-specific profiles | 1.14.13.98 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.98 |
| IUBMB Enzyme Nomenclature | 1.14.13.98 |
| IntEnz | 1.14.13.98 |
| MEDLINE | Find literature relating to 1.14.13.98 |
| MetaCyc | 1.14.13.98 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-